Population Genetics Models of Local Ancestry
نویسندگان
چکیده
منابع مشابه
Population genetics models of local ancestry.
Migrations have played an important role in shaping the genetic diversity of human populations. Understanding genomic data thus requires careful modeling of historical gene flow. Here we consider the effect of relatively recent population structure and gene flow and interpret genomes of individuals that have ancestry from multiple source populations as mosaics of segments originating from each ...
متن کاملPopulation Genetics: Difference Equation Models
The diversity of life is a fundamental empirical fact of nature. Casual observation alone confirms the great variety of species. But diversity also prevails within single species. As in human populations, the individuals of a species vary considerably in their outward traits—size and shape, external markings, fecundity, disease resistance, etc. This is called phenotypic variation, and, since ph...
متن کاملThe molecular genetics of European ancestry.
In an earlier paper we proposed, on the basis of mitochondrial control region variation, that the bulk of modern European mitochondrial DNA(mtDNA) diversity had its roots in the European Upper Palaeolithic. Refining the mtDNA phylogeny and enlarging the sample size both within Europe and the Middle East still support this interpretation and indicate three separate phases of colonization: (i) th...
متن کاملEfficient inference of local ancestry
MOTIVATION The inference of local ancestry of admixed individuals at every locus provides the basis for admixture mapping. Local ancestry information has been used to identify genetic susceptibility loci. RESULTS In this study, we developed a statistical method, efficient inference of local ancestry (EILA), which uses fused quantile regression and k-means classifier to infer the local ancestr...
متن کاملSome Mathematical Models from Population Genetics
1 Mutation and Random genetic drift 4 1.1 The Wright-Fisher model and the Kingman coalescent . . . . . . . . . . . . . . . . . . . 4 1.2 The Cannings model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 1.3 Adding mutations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 1.4 Inferring genealogies from data . . . . . . . . . . . . . ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genetics
سال: 2012
ISSN: 1943-2631
DOI: 10.1534/genetics.112.139808